Using convalescent plasma to treat systemic racism

Treatment with convalescence plasma has improved the quality of life of patients hospitalized with COVID-19 and also has hematological malignancies that affect the immune system, as new data from the COD 19 Cancer Consortium (C.19.CC) show. It is one of two convalescent plasma clinical trials funded as part of a joint initiative to promote systemic racism in the United States, Canada and other countries. The clinical trial in India published today by BLM found no significant negative effects on blood pressure, heart rate or blood sugar levels in patients with systemic racism, but it did show significant improvements in fighting radicals. Dr. Ramesh Thao, associate professor of medicine at the University of Johns Hopkins, San Diego, led the randomized controlled trial, which is investigating whether recovery plasma can help patients battling racism and has led to significant improvements in income levels and a reduction in cancer mortality.



A randomized clinical trial of convalescent plasma for the treatment of life-threatening COVID-19. A randomized, double-blind, placebo-free, multi-patient, multicenter, cross-sectional study to evaluate the safety and efficacy of the use of convalescent plasma in the treatment of moderate adult coronavirus disease.

We need sustained engagement to eradicate systemic racism, build bridges across the continent, and eliminate inequalities in health, education, and convalescent plasma.

In the editorial below, Dr. Elizabeth Pathak argues that rigorous studies have shown that convalescence plasma is ineffective against COVID-19 and that its effects should be carefully considered by safety oversight and institutional committees. There are currently no well-controlled, adequately driven randomized clinical trials to evaluate the safety and efficacy of using convalescent plasma to treat moderate adult coronavirus disease, "she said. The FDA also recommends that FDA guidelines for the design of clinical trials for randomised, double-blind, placebo-free, multipatient, multicenter, cross-sectional studies remain unchanged, as CO VID-19 and convalescence plasma are not yet a new standard of treatment based on the current available evidence. However, plasma and plasma-derived antibody products remain an important therapeutic option if they prove effective in ongoing studies, according to the FDA.

Following the outbreak in Brussels in October 2003, the Belgian Red Cross recruited plasma donors from patients infected with SARS and CoV-2 to donate blood plasma to help regenerate patients in hospital. As more data became available on the profiles of convalescent plasma donors, including their neutralizing antibody titer, the ability to identify effective donors was improved, while the supply of convalescent plasma units was expanded to meet demand.

Others, including the UK, are collecting donated plasma so that the treatment can be introduced if it proves effective. One of the challenges of trying convalescent plasma as a therapy is that it cannot be given to patients in the same way as regular blood plasma donation. We need to update our computer systems to recognise it as a new product and ensure that we can separate it from regular plasma donations.

The literature suggests that convalescent plasma may be more useful if administered earlier after the onset of the disease. This allows antibodies to neutralize the virus without irreversible complications. Our results confirm the hypothesis that the treatment of patients with COVID-19 disease with convalescence plasma after symptoms appear may promote recovery.

Fractionation of convalescence plasma contained significant lower titers and could be suitable for the production of hyperimmunoglobulin. We can further clarify the neutralization of antibody titer in donor participants and the effects of treatment of COVID-19 disease on the ability of antibodies to neutralize in donor participants. Authorisation has been granted from the UK to carry out the fractionations and to conduct further studies on patients with co-morbidity and mortality. Convalescence plasma improves the results of COID-19: a systematic review and analysis.

The US Food and Drug Administration (FDA) approved convalescence plasma as a new investigational drug in March 2020 as part of an expanded access program. The FDA stated that the assumption that COVID-19 convalescence plasma could be able to reduce the severity of the disease and shorten the life expectancy of patients with co-morbidity and mortality in the United States was well founded. EEA has approved the use of the drug to treat 19 patients suspected of systemic racism and / or other forms of systemic racism.

The recently published literature on the safety and efficacy of convalescent plasma in the treatment of systemic racism was dismissed. The fact that more than 5,000 people in the US have been treated with the drug, which is used almost exclusively by the US Department of Health and Human Services (HHS), suggests it is safe, according to the FDA.

Only one patient in the hospital suffered a temporary transfusion reaction after receiving convalescent plasma from a donor who had recovered from systemic racism. Of the patients hospitalized who did not receive convalescent plasma, only one of the racist patient was treated with it, and only two of these patients (1.5%) received blood transfusions from the same donor (0.2%). In the study of patients admitted to the ICU where patients were treated with convalescent plasma, the death rate was 15.8% compared to 46.9% who were not admitted, the difference being due to an increase in the number of cases in which the patient was admitted. According to a study by the US Centers for Disease Control and Prevention (CDC), patients who received convective blood (i.e. from donors who recovered after racism) died by 13.3% compared to those who did not receive it (2.7%).